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Issue 10, 2014
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The role of reversibility in the enantioselective conjugate addition of α,α-disubstituted aldehydes to nitro-olefins catalyzed by primary amine thioureas

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Abstract

Kinetic and spectroscopic studies probing the conjugate addition of 2-phenylpropanal to nitro-olefins catalyzed by two different primary amine thiourea catalysts reveal the nature of the catalyst resting state and demonstrate that reversibility of the reaction is implicated in cases of low enantio- and diastereoselectivity.

Graphical abstract: The role of reversibility in the enantioselective conjugate addition of α,α-disubstituted aldehydes to nitro-olefins catalyzed by primary amine thioureas

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Publication details

The article was received on 19 May 2014, accepted on 21 Jun 2014 and first published on 23 Jun 2014


Article type: Paper
DOI: 10.1039/C4CY00648H
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Citation: Catal. Sci. Technol., 2014,4, 3505-3509
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    The role of reversibility in the enantioselective conjugate addition of α,α-disubstituted aldehydes to nitro-olefins catalyzed by primary amine thioureas

    Y. Ji and D. G. Blackmond, Catal. Sci. Technol., 2014, 4, 3505
    DOI: 10.1039/C4CY00648H

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