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Issue 3, 2014
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A mild route for one pot synthesis of 5,6-unsubstituted 1,4-dihydropyridines catalyzed by sulphated mixed metal oxides

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Abstract

Synthesis of 1,4-dihydropyridines via a four component one pot reaction starting from α,β-unsaturated aldehyde, β-keto ester, amine and alcohol, catalysed by SO42−/CexZr1−xO2 is explored. The method has several advantages such as reusability of catalyst, avoidance of a multistep procedure and readily available starting materials. The protocol gives high to moderate yields for structurally diverse amines, β-keto esters and α,β-unsaturated aldehydes. SO42−/CexZr1−xO2 (x = 0.02–0.15 mol%) catalysts were prepared and characterized by various analytical techniques such as XRD, FT-IR, TGA-DSC, SEM-EDAX and the total acidity.

Graphical abstract: A mild route for one pot synthesis of 5,6-unsubstituted 1,4-dihydropyridines catalyzed by sulphated mixed metal oxides

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Publication details

The article was received on 30 Aug 2013, accepted on 12 Nov 2013 and first published on 20 Dec 2013


Article type: Paper
DOI: 10.1039/C3CY00651D
Citation: Catal. Sci. Technol., 2014,4, 672-680
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    A mild route for one pot synthesis of 5,6-unsubstituted 1,4-dihydropyridines catalyzed by sulphated mixed metal oxides

    S. S. Kahandal, S. R. Kale, M. B. Gawande and R. V. Jayaram, Catal. Sci. Technol., 2014, 4, 672
    DOI: 10.1039/C3CY00651D

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