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Issue 17, 2014
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Point-of-care biochemical assays using gold nanoparticle-implemented microfluidics

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Abstract

One of the goals of point-of-care (POC) is a chip-based, miniaturized, portable, self-containing system that allows the assay of proteins, nucleic acids, and cells in complex samples. The integration of nanomaterials and microfluidics can help achieve this goal. This tutorial review outlines the mechanism of assaying biomarkers by gold nanoparticles (AuNPs), and the implementation of AuNPs for microfluidic POC devices. In line with this, we discuss some recent advances in AuNP-coupled microfluidic sensors with enhanced performance. Portable and automated instruments for device operation and signal readout are also included for practical applications of these AuNP-combined microfluidic chips.

Graphical abstract: Point-of-care biochemical assays using gold nanoparticle-implemented microfluidics

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Publication details

The article was received on 06 Apr 2014 and first published on 02 Jun 2014


Article type: Tutorial Review
DOI: 10.1039/C4CS00125G
Citation: Chem. Soc. Rev., 2014,43, 6239-6253
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    Point-of-care biochemical assays using gold nanoparticle-implemented microfluidics

    J. Sun, Y. Xianyu and X. Jiang, Chem. Soc. Rev., 2014, 43, 6239
    DOI: 10.1039/C4CS00125G

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