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Issue 13, 2014
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The OPEP protein model: from single molecules, amyloid formation, crowding and hydrodynamics to DNA/RNA systems

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Abstract

The OPEP coarse-grained protein model has been applied to a wide range of applications since its first release 15 years ago. The model, which combines energetic and structural accuracy and chemical specificity, allows the study of single protein properties, DNA–RNA complexes, amyloid fibril formation and protein suspensions in a crowded environment. Here we first review the current state of the model and the most exciting applications using advanced conformational sampling methods. We then present the current limitations and a perspective on the ongoing developments.

Graphical abstract: The OPEP protein model: from single molecules, amyloid formation, crowding and hydrodynamics to DNA/RNA systems

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Publication details

The article was received on 28 Jan 2014 and first published on 23 Apr 2014


Article type: Review Article
DOI: 10.1039/C4CS00048J
Author version available: Download Author version (PDF)
Citation: Chem. Soc. Rev., 2014,43, 4871-4893
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    The OPEP protein model: from single molecules, amyloid formation, crowding and hydrodynamics to DNA/RNA systems

    F. Sterpone, S. Melchionna, P. Tuffery, S. Pasquali, N. Mousseau, T. Cragnolini, Y. Chebaro, J. St-Pierre, M. Kalimeri, A. Barducci, Y. Laurin, A. Tek, M. Baaden, P. H. Nguyen and P. Derreumaux, Chem. Soc. Rev., 2014, 43, 4871
    DOI: 10.1039/C4CS00048J

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