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Issue 34, 2014
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The mechanical response of hIAPP nanowires based on different bending direction simulations

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Abstract

Amyloid proteins, implicated in numerous aging-related diseases, possess remarkable mechanical properties. Polymorphism leads to different arrangements of β sheets in amyloid fibrils, which changes the characteristics of the hydrogen bond network that determines their mechanical properties and structural characteristics. We performed bending simulations using molecular dynamics methods under constant-velocity conditions in different bending directions. Two different fibril structures, parallel/homo and parallel/hetero, of hIAPP amyloids were considered. Though the bending configuration influences the toughness of the material, our results indicate that the basic material behavior is affected by the β-sheet arrangement that is determined by the type of polymorphism in amyloid fibrils.

Graphical abstract: The mechanical response of hIAPP nanowires based on different bending direction simulations

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Publication details

The article was received on 06 Jun 2014, accepted on 21 Jul 2014 and first published on 22 Jul 2014


Article type: Paper
DOI: 10.1039/C4CP02494J
Citation: Phys. Chem. Chem. Phys., 2014,16, 18493-18500
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    The mechanical response of hIAPP nanowires based on different bending direction simulations

    J. I. Kim, M. Lee, I. Baek, G. Yoon and S. Na, Phys. Chem. Chem. Phys., 2014, 16, 18493
    DOI: 10.1039/C4CP02494J

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