Issue 30, 2014

Structural and physicochemical aspects of hydrochlorothiazide co-crystals

Abstract

Crystal engineering principles were employed in designing new co-crystals of hydrochlorothiazide (HCT). A variety of potential co-crystal formers were initially identified in a search of the Cambridge Structural Database with complementary hydrogen-bonding functionalities. Subsequent co-crystallization screening monitored by powder X-ray diffraction led to the discovery of new crystalline phases of HCT with pyrazinamide (1), 4,4′-bipyridine (2), 1,2-bis(4-pyridyl)ethane (3), and trans-1,2-bis(4-pyridyl)ethylene (4). All of the resulting co-crystals were thoroughly characterized by X-ray diffraction, FT-IR and Raman spectroscopy, and thermal analysis. Noticeably, the co-crystal 1 involves the formation of drug–drug co-crystals of HCT and pyrazinamide, which makes it a potential candidate for development of HCT formulations for combinational therapy.

Graphical abstract: Structural and physicochemical aspects of hydrochlorothiazide co-crystals

Supplementary files

Article information

Article type
Paper
Submitted
31 Mar 2014
Accepted
01 Jun 2014
First published
02 Jun 2014

CrystEngComm, 2014,16, 6996-7003

Author version available

Structural and physicochemical aspects of hydrochlorothiazide co-crystals

J. Wang, C. Ye and X. Mei, CrystEngComm, 2014, 16, 6996 DOI: 10.1039/C4CE00666F

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