Jump to main content
Jump to site search

Issue 17, 2014
Previous Article Next Article

Continuous cocrystallisation of carbamazepine and trans-cinnamic acid via melt extrusion processing

Author affiliations

Abstract

A solvent free process for the formation of carbamazepine (CBZ)–trans-cinnamic acid (TCA) cocrystals, in stoichiometric ratios, was developed using continuous hot melt extrusion processing. Physicochemical characterization of the CBZ–TCA extrudates included scanning electron microscopy (SEM), differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD) and hot stage microscopy to evaluate the shape, morphology, purity and crystallinity of the freshly made cocrystals. The obtained cocrystals were of high quality compared to the prototype produced by a solvent crystallization technique. Furthermore, an in-line NIR probe was used to investigate the gradual formation of cocrystals during extrusion processing. The quality of the CBZ–TCA cocrystals was found to depend on the processing parameters such as temperature and the screw type. The extruded cocrystals showed faster dissolution rates compared to bulk CBZ and the prototype cocrystals.

Graphical abstract: Continuous cocrystallisation of carbamazepine and trans-cinnamic acid via melt extrusion processing

Back to tab navigation

Supplementary files

Publication details

The article was received on 02 Dec 2013, accepted on 16 Feb 2014 and first published on 17 Feb 2014


Article type: Paper
DOI: 10.1039/C3CE42457J
Author version
available:
Download author version (PDF)
Citation: CrystEngComm, 2014,16, 3573-3583
  •   Request permissions

    Continuous cocrystallisation of carbamazepine and trans-cinnamic acid via melt extrusion processing

    H. G. Moradiya, M. T. Islam, S. Halsey, M. Maniruzzaman, B. Z. Chowdhry, M. J. Snowden and D. Douroumis, CrystEngComm, 2014, 16, 3573
    DOI: 10.1039/C3CE42457J

Search articles by author

Spotlight

Advertisements