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Issue 89, 2014
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Esterase-activated release of naproxen from supramolecular nanofibres

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Abstract

Nanofibre forming peptide amphiphiles were conjugated to naproxen through an esterase-sensitive linker. The amount of naproxen released, in the presence of enzymes, was influenced by the linker conjugating the drug to the supramolecular assembly. In vitro studies showed the anti-inflammatory activity of the released drug was maintained.

Graphical abstract: Esterase-activated release of naproxen from supramolecular nanofibres

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Publication details

The article was received on 12 Aug 2014, accepted on 18 Sep 2014 and first published on 24 Sep 2014


Article type: Communication
DOI: 10.1039/C4CC06340F
Citation: Chem. Commun., 2014,50, 13757-13760
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    Esterase-activated release of naproxen from supramolecular nanofibres

    M. Conda-Sheridan, S. S. Lee, A. T. Preslar and S. I. Stupp, Chem. Commun., 2014, 50, 13757
    DOI: 10.1039/C4CC06340F

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