Issue 57, 2014

Ti(OiPr)4/nBuLi: an attractive reagent system for [2+2+2] cyclotrimerisation reactions

Abstract

A convenient method for the [2+2+2] cyclotrimerisation of alkynes using Ti(OiPr)4/nBuLi is presented. Homotrimerisation of arylacetylenes proceeds within minutes with excellent regioselectivity. Moreover, the intermolecular construction of ABB heterotrimers can be achieved selectively from two different alkynes with similar electronic properties. The method is also suitable for the synthesis of pyridines.

Graphical abstract: Ti(OiPr)4/nBuLi: an attractive reagent system for [2+2+2] cyclotrimerisation reactions

Supplementary files

Article information

Article type
Communication
Submitted
11 Apr 2014
Accepted
18 May 2014
First published
28 May 2014

Chem. Commun., 2014,50, 7666-7669

Ti(OiPr)4/nBuLi: an attractive reagent system for [2+2+2] cyclotrimerisation reactions

V. A. Rassadin, E. Nicolas and Y. Six, Chem. Commun., 2014, 50, 7666 DOI: 10.1039/C4CC02698E

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