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Issue 51, 2014
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An ensemble of aptamers and antibodies for multivalent capture of cancer cells

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Abstract

We developed an optimized ensemble of aptamers and antibodies that functions as a multivalent adhesive domain for the capture and isolation of cancer cells. When incorporated into a microfluidic device, the ensemble showed not only high capture efficiency, but also superior capture selectivity at a high shear stress (or high flow rate).

Graphical abstract: An ensemble of aptamers and antibodies for multivalent capture of cancer cells

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Publication details

The article was received on 17 Mar 2014, accepted on 30 Apr 2014 and first published on 02 May 2014


Article type: Communication
DOI: 10.1039/C4CC02002B
Citation: Chem. Commun., 2014,50, 6722-6725
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    An ensemble of aptamers and antibodies for multivalent capture of cancer cells

    J. Zhang, W. Sheng and Z. H. Fan, Chem. Commun., 2014, 50, 6722
    DOI: 10.1039/C4CC02002B

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