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Issue 23, 2014
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N-Methyl and peptoid scans of an autoinducing peptide reveal new structural features required for inhibition and activation of AgrC quorum sensing receptors in Staphylococcus aureus

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Abstract

We report the first N-methyl and peptoid residue scans of a full-length autoinducing peptide (AIP), AIP-III, used by Staphylococcus aureus for quorum sensing (QS). Biological evaluation of these AIP-III analogues uncovered new features of the AIP-III scaffold that can be tuned to develop chemical probes of QS in all four groups of S. aureus (I–IV).

Graphical abstract: N-Methyl and peptoid scans of an autoinducing peptide reveal new structural features required for inhibition and activation of AgrC quorum sensing receptors in Staphylococcus aureus

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Publication details

The article was received on 06 Jan 2014, accepted on 29 Jan 2014 and first published on 31 Jan 2014


Article type: Communication
DOI: 10.1039/C4CC00117F
Author version available: Download Author version (PDF)
Citation: Chem. Commun., 2014,50, 3000-3003
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    N-Methyl and peptoid scans of an autoinducing peptide reveal new structural features required for inhibition and activation of AgrC quorum sensing receptors in Staphylococcus aureus

    Y. Tal-Gan, D. M. Stacy and H. E. Blackwell, Chem. Commun., 2014, 50, 3000
    DOI: 10.1039/C4CC00117F

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