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Issue 35, 2014
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Anti-cancer therapeutic potential of quinazoline based small molecules via global upregulation of miRNAs

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Abstract

Three quinazoline based small molecules showed global upregulation of miRNA expression with a selective enrichment of tumor suppressor miRNAs. The target genes of the upregulated miRNAs were predicted to be enriched for apoptotic pathways. Apoptotic induction following treatment with quinazoline compounds was confirmed by in cellulo studies. Thus, these small molecules having the core structural moiety (2,4-diphenyl-quinazoline) can be used as scaffolds to design activators of miRNA expression paving the way for novel anti-cancer drugs.

Graphical abstract: Anti-cancer therapeutic potential of quinazoline based small molecules via global upregulation of miRNAs

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Publication details

The article was received on 09 Dec 2013, accepted on 28 Feb 2014 and first published on 11 Mar 2014


Article type: Communication
DOI: 10.1039/C3CC49337G
Citation: Chem. Commun., 2014,50, 4639-4642
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    Anti-cancer therapeutic potential of quinazoline based small molecules via global upregulation of miRNAs

    S. Nahar, D. Bose, S. Kumar Panja, S. Saha and S. Maiti, Chem. Commun., 2014, 50, 4639
    DOI: 10.1039/C3CC49337G

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