Issue 19, 2014
From the journal:

Chemical Communications

Stabilized porous liposomes with encapsulated Gd-labeled dextran as a highly efficient MRI contrast agent†

Zhiliang Cheng,*a   Ajlan Al Zaki,a   Ian W. Jones,b   Henry K. Hall, Jr.,b   Craig A. Aspinwallb  and  Andrew Tsourkasa  

* Corresponding authors

a Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
E-mail: zcheng@seas.upenn.edu
Fax: +1-215-573-2071
Tel: +1-215-573-0290

b Department of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona 85721, USA

Abstract

A highly efficient contrast agent for magnetic resonance imaging was developed by encapsulating gadolinium within a stabilized porous liposome. The highly porous membrane leads to a high relaxivity of the encapsulated Gd. The stability of the liposome was improved by forming a polymer network within the bilayer membrane.

Graphical abstract: Stabilized porous liposomes with encapsulated Gd-labeled dextran as a highly efficient MRI contrast agent

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Article information

DOI
https://doi.org/10.1039/C3CC48939F
Article type
Communication
Submitted
22 Nov 2013
Accepted
12 Jan 2014
First published
13 Jan 2014

Chem. Commun., 2014,50, 2502-2504

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Stabilized porous liposomes with encapsulated Gd-labeled dextran as a highly efficient MRI contrast agent

Z. Cheng, A. Al Zaki, I. W. Jones, H. K. Hall, C. A. Aspinwall and A. Tsourkas, Chem. Commun., 2014, 50, 2502 DOI: 10.1039/C3CC48939F

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