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Issue 19, 2014
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Conjugation of vitamin E analog α-TOS to Pt(IV) complexes for dual-targeting anticancer therapy

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Abstract

We report two platinum(IV) complexes conjugated with a vitamin E analog, α-tocopherol succinate (α-TOS). One of the conjugates displays the activity of both cisplatin and α-TOS in cancer cells, causing damage to DNA and mitochondria simultaneously. Accordingly, it serves as a promising dual-targeting anticancer agent.

Graphical abstract: Conjugation of vitamin E analog α-TOS to Pt(iv) complexes for dual-targeting anticancer therapy

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Publication details

The article was received on 15 Nov 2013, accepted on 10 Dec 2013 and first published on 11 Dec 2013


Article type: Communication
DOI: 10.1039/C3CC48740G
Citation: Chem. Commun., 2014,50, 2465-2468
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    Conjugation of vitamin E analog α-TOS to Pt(IV) complexes for dual-targeting anticancer therapy

    K. Suntharalingam, Y. Song and S. J. Lippard, Chem. Commun., 2014, 50, 2465
    DOI: 10.1039/C3CC48740G

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