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Issue 14, 2014
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Enzyme-triggered gelation: targeting proteases with internal cleavage sites

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Abstract

A generalizable method for detecting protease activity via gelation is described. A recognition sequence is used to target the protease of interest while a second protease is used to remove the residual residues from the gelator scaffold. Using this approach, selective assays for both MMP-9 and PSA are demonstrated.

Graphical abstract: Enzyme-triggered gelation: targeting proteases with internal cleavage sites

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Publication details

The article was received on 23 Oct 2013, accepted on 18 Dec 2013 and first published on 19 Dec 2013


Article type: Communication
DOI: 10.1039/C3CC48132H
Citation: Chem. Commun., 2014,50, 1691-1693
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    Enzyme-triggered gelation: targeting proteases with internal cleavage sites

    S. C. Bremmer, A. J. McNeil and M. B. Soellner, Chem. Commun., 2014, 50, 1691
    DOI: 10.1039/C3CC48132H

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