Dual stimuli-responsive multi-drug delivery system for the individually controlled release of anti-cancer drugs

Wang Xiao; Xuan Zeng; Hang Lin; Kai Han; Hui-Zhen Jia; Xian-Zheng Zhang

doi:10.1039/C4CC08831J

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Dual stimuli-responsive multi-drug delivery system for the individually controlled release of anti-cancer drugs†

Wang Xiao,‡^a Xuan Zeng,‡^a Hang Lin,^a Kai Han,^a Hui-Zhen Jia^a and Xian-Zheng Zhang*^a

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* Corresponding authors

^a Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan 430072, P. R. China
E-mail: xz-zhang@whu.edu.cn
Fax: +86 27 6875 4509
Tel: +86 27 6875 5993

Abstract

A dual stimuli-responsive multi-drug delivery system was developed for “cancer cocktail therapy”. Upon UV irradiation, microcapsules could rapidly release the small-molecule drugs, and thereafter the macromolecular drugs would be released in the presence of MMP in the tumor cells. This system will find great potential as a novel chemotherapeutic combination for cancer treatment.

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Article information

DOI: https://doi.org/10.1039/C4CC08831J
Article type: Communication
Submitted: 05 Nov 2014
Accepted: 24 Nov 2014
First published: 26 Nov 2014

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Chem. Commun., 2015,51, 1475-1478

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Dual stimuli-responsive multi-drug delivery system for the individually controlled release of anti-cancer drugs

W. Xiao, X. Zeng, H. Lin, K. Han, H. Jia and X. Zhang, Chem. Commun., 2015, 51, 1475 DOI: 10.1039/C4CC08831J

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Chemical Communications

Dual stimuli-responsive multi-drug delivery system for the individually controlled release of anti-cancer drugs†

Abstract

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Dual stimuli-responsive multi-drug delivery system for the individually controlled release of anti-cancer drugs

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