Issue 4, 2015
From the journal:

Chemical Communications

Pd-Catalyzed direct C–H functionalization of imidazolones with aryl- and alkenyl halides†

Mickaël Muselli,a   Christine Baudequin,a   Christophe Hoarau*a  and  Laurent Bischoff*a  

* Corresponding authors

a Mickaël Muselli, Christine Baudequin, Christophe Hoarau, Laurent Bischoff Normandie Univ, COBRA, UMR 6014 et FR 3038, Univ Rouen, INSA Rouen, CNRS, IRCOF, 1 rue Tesnière, 76821 Mont Saint Aignan Cedex, France
E-mail: christophe.hoarau@insa-rouen.fr, laurent.bischoff@insa-rouen.fr

Abstract

Direct C–H arylation and alkenylation of 4,4′-dialkylimidazolones with a broad range of halides under palladium and copper catalysis have been developed. This methodology is applied to the preparation of recently discovered fatty acid synthetase (FAS) inhibitors.

Graphical abstract: Pd-Catalyzed direct C–H functionalization of imidazolones with aryl- and alkenyl halides

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Article information

DOI
https://doi.org/10.1039/C4CC07917E
Article type
Communication
Submitted
07 Oct 2014
Accepted
20 Nov 2014
First published
20 Nov 2014

Chem. Commun., 2015,51, 745-748

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Pd-Catalyzed direct C–H functionalization of imidazolones with aryl- and alkenyl halides

M. Muselli, C. Baudequin, C. Hoarau and L. Bischoff, Chem. Commun., 2015, 51, 745 DOI: 10.1039/C4CC07917E

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