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Issue 100, 2014
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A click-and-release approach to CO prodrugs

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Abstract

Carbon monoxide belongs to the family of signaling molecules and has been shown to possess therapeutic effects. Similar to NO, safe delivery of CO is a key issue in developing CO-based therapeutics. Herein we report a “click and release” CO-prodrug approach, which allows the release of CO under physiological conditions without the need for light irradiation. The system releases CO in a triggered and controllable manner and possesses the potential of tunable release rates.

Graphical abstract: A click-and-release approach to CO prodrugs

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Publication details

The article was received on 03 Oct 2014, accepted on 31 Oct 2014 and first published on 31 Oct 2014


Article type: Communication
DOI: 10.1039/C4CC07748B
Citation: Chem. Commun., 2014,50, 15890-15893
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    A click-and-release approach to CO prodrugs

    D. Wang, E. Viennois, K. Ji, K. Damera, A. Draganov, Y. Zheng, C. Dai, D. Merlin and B. Wang, Chem. Commun., 2014, 50, 15890
    DOI: 10.1039/C4CC07748B

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