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Issue 90, 2014
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Multicomponent decarboxylative allylations

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Abstract

The reaction of Meldrum's acid, pyrrolide, and allyl carbonates allows a multicomponent decarboxylative coupling to form allylated acyl pyrroles. This strategy is made possible by the in situ formation of β-oxo carboxylates from Meldrum's acid. Subsequent decarboxylative enolate formation and electrophilic allylation complete the reaction. Addition of benzylidene malononitriles as good Michael acceptors allow a 4-component interceptive decarboxylative allylation.

Graphical abstract: Multicomponent decarboxylative allylations

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Publication details

The article was received on 13 Sep 2014, accepted on 24 Sep 2014 and first published on 25 Sep 2014


Article type: Communication
DOI: 10.1039/C4CC07253G
Citation: Chem. Commun., 2014,50, 14049-14052
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    Multicomponent decarboxylative allylations

    Y. Ariyarathna and J. A. Tunge, Chem. Commun., 2014, 50, 14049
    DOI: 10.1039/C4CC07253G

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