Issue 12, 2015

Intramolecular Schmidt reaction of acyl chlorides with alkyl azides: preparation of pyrrolizine by intramolecular capture of intermediates with alkenes or alkynes

Abstract

The preparation of substituted pyrrolizines through the Schmidt reaction of acyl chlorides with alkyl azides has been realized. Intramolecular capture of the isocyanate ion and N-acyliminium ion intermediates from the Schmidt process with alkene or alkyne units was achieved, and the efficiency of the conversion with respect to ring construction and bond formation was demonstrated.

Graphical abstract: Intramolecular Schmidt reaction of acyl chlorides with alkyl azides: preparation of pyrrolizine by intramolecular capture of intermediates with alkenes or alkynes

Supplementary files

Article information

Article type
Communication
Submitted
11 Sep 2014
Accepted
15 Dec 2014
First published
17 Dec 2014

Chem. Commun., 2015,51, 2277-2279

Intramolecular Schmidt reaction of acyl chlorides with alkyl azides: preparation of pyrrolizine by intramolecular capture of intermediates with alkenes or alkynes

B. Wang, P. Xue and P. Gu, Chem. Commun., 2015, 51, 2277 DOI: 10.1039/C4CC07166B

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