Issue 98, 2014
From the journal:

Chemical Communications

Acetal-linked branched poly(dimethyl-aminoethyl methacrylate) as an acid cleavable gene vector with reduced cytotoxicity†

H. L. Cao,*ab   Y. X. Dong,c   A. Aied,c   T. Y. Zhao,c   X. Chen,ab   W. X. Wang*c  and  A. Pandit*d  

* Corresponding authors

a Key Laboratory for Ultrafine Materials of Ministry of Education, and Shanghai Key Laboratory of Advanced Polymeric Materials, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China
E-mail: caohl@ecust.edu.cn

b State Key Laboratory of Bioreactor Engineering, Biomedical Nanotechnology Center, East China University of Science and Technology, Shanghai 200237, P. R. China

c Charles Institute of Dermatology, University College Dublin, Ireland
E-mail: wenxin.wang@ucd.ie

d Network of Excellence for Functional Biomaterials, National University of Ireland, Galway, Ireland
E-mail: abhay.pandit@nuigalway.ie

Abstract

An acid labile branched PDMAEMA/acetal copolymer with amino group was synthesized by the DE-ATRP and followed by Michael addition. The degradation of the polymer was strongly pH-dependent. High nucleic acid transfection efficiency with low cytotoxicity was observed compared to its non-degradable copolymer counterpart.

Graphical abstract: Acetal-linked branched poly(dimethyl-aminoethyl methacrylate) as an acid cleavable gene vector with reduced cytotoxicity

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Article information

DOI
https://doi.org/10.1039/C4CC06728B
Article type
Communication
Submitted
28 Aug 2014
Accepted
20 Oct 2014
First published
22 Oct 2014

Chem. Commun., 2014,50, 15565-15568

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Acetal-linked branched poly(dimethyl-aminoethyl methacrylate) as an acid cleavable gene vector with reduced cytotoxicity

H. L. Cao, Y. X. Dong, A. Aied, T. Y. Zhao, X. Chen, W. X. Wang and A. Pandit, Chem. Commun., 2014, 50, 15565 DOI: 10.1039/C4CC06728B

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