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Issue 98, 2014
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Acetal-linked branched poly(dimethyl-aminoethyl methacrylate) as an acid cleavable gene vector with reduced cytotoxicity

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Abstract

An acid labile branched PDMAEMA/acetal copolymer with amino group was synthesized by the DE-ATRP and followed by Michael addition. The degradation of the polymer was strongly pH-dependent. High nucleic acid transfection efficiency with low cytotoxicity was observed compared to its non-degradable copolymer counterpart.

Graphical abstract: Acetal-linked branched poly(dimethyl-aminoethyl methacrylate) as an acid cleavable gene vector with reduced cytotoxicity

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Publication details

The article was received on 28 Aug 2014, accepted on 20 Oct 2014 and first published on 22 Oct 2014


Article type: Communication
DOI: 10.1039/C4CC06728B
Citation: Chem. Commun., 2014,50, 15565-15568
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    Acetal-linked branched poly(dimethyl-aminoethyl methacrylate) as an acid cleavable gene vector with reduced cytotoxicity

    H. L. Cao, Y. X. Dong, A. Aied, T. Y. Zhao, X. Chen, W. X. Wang and A. Pandit, Chem. Commun., 2014, 50, 15565
    DOI: 10.1039/C4CC06728B

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