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Issue 86, 2014
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Catalytic imine–imine cross-coupling reactions

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We report here efficient catalytic imine–imine cross-coupling reactions based on an umpolung strategy; an imine bearing a 9-fluorenyl moiety on its nitrogen atom, which acted as a nucleophile, reacted with another imine to afford an imine–imine cross-coupling adduct in high yield. Furthermore, a chiral guanidine acted as a chiral catalyst for these coupling reactions, and optically active 1,2-diamines were obtained in high yields with high enantioselectivities.

Graphical abstract: Catalytic imine–imine cross-coupling reactions

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The article was received on 06 Aug 2014, accepted on 29 Aug 2014 and first published on 29 Aug 2014

Article type: Communication
DOI: 10.1039/C4CC06156J
Citation: Chem. Commun., 2014,50, 13041-13044
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    Catalytic imine–imine cross-coupling reactions

    M. Matsumoto, M. Harada, Y. Yamashita and S. Kobayashi, Chem. Commun., 2014, 50, 13041
    DOI: 10.1039/C4CC06156J

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