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Issue 81, 2014
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Synthesis of 1,2-amino alcohols via catalytic C–H amidation of sp3 methyl C–H bonds

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Abstract

Herein a new synthetic route to 1,2-amino alcohols is presented by using C–H amidation of sp3 methyl C–H bonds as a key step. Readily available alcohols were employed as starting materials after converting them to removable ketoxime chelating groups. Iridium catalysts were found to be effective for the C–H amidation, and LAH reduction was then used to furnish β-amino alcohol products.

Graphical abstract: Synthesis of 1,2-amino alcohols via catalytic C–H amidation of sp3 methyl C–H bonds

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Publication details

The article was received on 22 Jul 2014, accepted on 15 Aug 2014 and first published on 18 Aug 2014


Article type: Communication
DOI: 10.1039/C4CC05655H
Citation: Chem. Commun., 2014,50, 12073-12075
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    Synthesis of 1,2-amino alcohols via catalytic C–H amidation of sp3 methyl C–H bonds

    T. Kang, H. Kim, J. G. Kim and S. Chang, Chem. Commun., 2014, 50, 12073
    DOI: 10.1039/C4CC05655H

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