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Issue 80, 2014
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Surface-enhanced Raman spectroscopy for simultaneous sensitive detection of multiple microRNAs in lung cancer cells

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Abstract

We develop circular exponential amplification reaction (EXPAR)-based surface-enhanced Raman spectroscopy (SERS) for simultaneous sensitive detection of multiple microRNAs in non-small cell lung cancer cells. This method possesses distinct advantages of excellent selectivity and high sensitivity with a detection limit of as low as 0.5 fM, which has improved by as much as 6 orders of magnitude as compared with the previously reported SERS-based direct assay.

Graphical abstract: Surface-enhanced Raman spectroscopy for simultaneous sensitive detection of multiple microRNAs in lung cancer cells

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Publication details

The article was received on 20 Jul 2014, accepted on 14 Aug 2014 and first published on 14 Aug 2014


Article type: Communication
DOI: 10.1039/C4CC05598E
Citation: Chem. Commun., 2014,50, 11883-11886
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    Surface-enhanced Raman spectroscopy for simultaneous sensitive detection of multiple microRNAs in lung cancer cells

    L. Ye, J. Hu, L. Liang and C. Zhang, Chem. Commun., 2014, 50, 11883
    DOI: 10.1039/C4CC05598E

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