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An ultrasensitive label-free electrochemical biosensor for microRNA-21 detection based on a 2′-O-methyl modified DNAzyme and duplex-specific nuclease assisted target recycling

Xi Zhang,a   Dongzhi Wu,a   Zhijing Liu,a   Shuxian Cai,a   Yanping Zhao,a   Mei Chen,a   Yaokun Xia,a   Chunyan Li,a   Jing Zhang*b and   Jinghua Chen*a  
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a
Department of Pharmaceutical Analysis, Faculty of Pharmacy, Fujian Medical University, Fuzhou, P. R. China
E-mail: cjh_huaxue@126.com;
Fax: +86-591-22862016 ;
Tel: +86-591-22862016
b
The Ministry of Education Key Laboratory of Biopesticide and Chemical Biology, and College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou, P. R. China
E-mail: 1601225385@qq.com;
Fax: +86-591-83769155 ;
Tel: +86-591-83769155
Chem. Commun., 2014,50, 12375-12377

DOI: 10.1039/C4CC05541A
Received 18 Jul 2014, Accepted 26 Aug 2014
First published online 26 Aug 2014
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