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Issue 82, 2014
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An ultrasensitive label-free electrochemical biosensor for microRNA-21 detection based on a 2′-O-methyl modified DNAzyme and duplex-specific nuclease assisted target recycling

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Abstract

Based on a highly efficient 2′-O-methyl modified G-quadruplex-hemin DNAzyme and duplex-specific nuclease (DSN) assisted target recycling, a novel label-free electrochemical biosensor for microRNA-21 (miR-21) detection is developed here. By employing the strategy, this DNA biosensor can detect as low as 8 aM miR-21 and exhibits high discrimination ability even against a single-base mismatch.

Graphical abstract: An ultrasensitive label-free electrochemical biosensor for microRNA-21 detection based on a 2′-O-methyl modified DNAzyme and duplex-specific nuclease assisted target recycling

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Publication details

The article was received on 18 Jul 2014, accepted on 26 Aug 2014 and first published on 26 Aug 2014


Article type: Communication
DOI: 10.1039/C4CC05541A
Citation: Chem. Commun., 2014,50, 12375-12377
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    An ultrasensitive label-free electrochemical biosensor for microRNA-21 detection based on a 2′-O-methyl modified DNAzyme and duplex-specific nuclease assisted target recycling

    X. Zhang, D. Wu, Z. Liu, S. Cai, Y. Zhao, M. Chen, Y. Xia, C. Li, J. Zhang and J. Chen, Chem. Commun., 2014, 50, 12375
    DOI: 10.1039/C4CC05541A

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