Solid phase microextraction (SPME)-transmission mode (TM) pushes down detection limits in direct analysis in real time (DART)

Abstract

A new SPME device was developed and applied for quick solventless extraction/enrichment of small molecules from complex matrices. Subsequently, the device was coupled as a transmission mode substrate to DART resulting in limits of detection in the low pg mL⁻¹ level in less than 3 minutes with reproducibility below 5% RSD.