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Issue 86, 2014
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Design of anticoagulant surfaces based on cellulose nanocrystals

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Abstract

The anticoagulant activity of surfaces decorated with cellulose nanocrystals (CNCs) prepared via sulfuric acid hydrolysis, is explored. Such surfaces bear a high amount of negatively charged sulfate groups, which mimic the naturally occurring anticoagulant heparin in terms of charge density. It is demonstrated that CNC decorated surfaces significantly enhance the coagulation times of blood plasma and whole blood as proven by QCM-D and simple clotting tests.

Graphical abstract: Design of anticoagulant surfaces based on cellulose nanocrystals

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Publication details

The article was received on 08 Jul 2014, accepted on 08 Sep 2014 and first published on 16 Sep 2014


Article type: Communication
DOI: 10.1039/C4CC05254D
Author version available: Download Author version (PDF)
Citation: Chem. Commun., 2014,50, 13070-13072
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    Design of anticoagulant surfaces based on cellulose nanocrystals

    H. M. A. Ehmann, T. Mohan, M. Koshanskaya, S. Scheicher, D. Breitwieser, V. Ribitsch, K. Stana-Kleinschek and S. Spirk, Chem. Commun., 2014, 50, 13070
    DOI: 10.1039/C4CC05254D

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