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Issue 77, 2014
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A prochelator with a modular masking group featuring hydrogen peroxide activation with concurrent fluorescent reporting

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Abstract

Metal chelators masked with protecting groups for targeted release have the potential to conditionally modulate cellular metals. We report a new route to prepare cis-cinnamate protecting groups that enabled development of a prochelator with chemical stimulus response, fluorescent reporting and active compound release in a single structure.

Graphical abstract: A prochelator with a modular masking group featuring hydrogen peroxide activation with concurrent fluorescent reporting

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Publication details

The article was received on 03 Jul 2014, accepted on 05 Aug 2014 and first published on 13 Aug 2014


Article type: Communication
DOI: 10.1039/C4CC05076B
Author version available: Download Author version (PDF)
Citation: Chem. Commun., 2014,50, 11317-11320
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    A prochelator with a modular masking group featuring hydrogen peroxide activation with concurrent fluorescent reporting

    A. T. Franks and K. J. Franz, Chem. Commun., 2014, 50, 11317
    DOI: 10.1039/C4CC05076B

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