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Issue 80, 2014
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Evaluation of molecules based on the electron donor–acceptor architecture as near-infrared β-amyloidal-targeting probes

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Abstract

A novel class of near-infrared molecules based on the donor–acceptor architecture were synthesized and evaluated as Aβ imaging probes. In vivo imaging studies suggested that MCAAD-3 could penetrate the blood–brain barrier and label Aβ plaques in the brains of transgenic mice. Computational studies could reproduce the experimental trends well.

Graphical abstract: Evaluation of molecules based on the electron donor–acceptor architecture as near-infrared β-amyloidal-targeting probes

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Publication details

The article was received on 27 Jun 2014, accepted on 31 Jul 2014 and first published on 15 Aug 2014


Article type: Communication
DOI: 10.1039/C4CC04907A
Citation: Chem. Commun., 2014,50, 11875-11878
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    Evaluation of molecules based on the electron donor–acceptor architecture as near-infrared β-amyloidal-targeting probes

    H. Fu, M. Cui, P. Tu, Z. Pan and B. Liu, Chem. Commun., 2014, 50, 11875
    DOI: 10.1039/C4CC04907A

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