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Issue 80, 2014
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An efficient one-pot strategy for the highly regioselective metal-free synthesis of 1,4-disubstituted-1,2,3-triazoles

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Abstract

A simple and efficient metal-free methodology for the regioselective synthesis of 1,4-disubstituted-1,2,3-triazoles has been developed by applying a novel inverse electron-demand-1,3-dipolar cycloaddition approach. The practical one-pot metal-free strategy can be accomplished with various alkylidene malononitriles and aromatic azides in the presence of base.

Graphical abstract: An efficient one-pot strategy for the highly regioselective metal-free synthesis of 1,4-disubstituted-1,2,3-triazoles

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Publication details

The article was received on 19 Jun 2014, accepted on 28 Jul 2014 and first published on 13 Aug 2014


Article type: Communication
DOI: 10.1039/C4CC04678A
Author version available: Download Author version (PDF)
Citation: Chem. Commun., 2014,50, 11926-11929
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    An efficient one-pot strategy for the highly regioselective metal-free synthesis of 1,4-disubstituted-1,2,3-triazoles

    A. Ali, A. G. Corrêa, D. Alves, J. Zukerman-Schpector, B. Westermann, M. A. B. Ferreira and M. W. Paixão, Chem. Commun., 2014, 50, 11926
    DOI: 10.1039/C4CC04678A

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