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Issue 74, 2014
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Measuring whole genome methylation via oxygen channelling chemistry

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Abstract

Successful use of demethylating drugs in cancers underscores the need to analyse whole genome DNA methylation in the clinic. Unfortunately, current methods are difficult to perform and require large amounts of DNA input. Herein we describe the first application of oxygen channelling chemistry for detecting DNA methylation which requires 2 hours to perform, 10-fold less input material than conventional methods, is sensitive to 5% difference in methylation and is able to differentiate samples before and after demethylating treatment.

Graphical abstract: Measuring whole genome methylation via oxygen channelling chemistry

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Publication details

The article was received on 18 Jun 2014, accepted on 28 Jul 2014 and first published on 28 Jul 2014


Article type: Communication
DOI: 10.1039/C4CC04623D
Author version available: Download Author version (PDF)
Citation: Chem. Commun., 2014,50, 10894-10896
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    Measuring whole genome methylation via oxygen channelling chemistry

    E. J. H. Wee and M. Trau, Chem. Commun., 2014, 50, 10894
    DOI: 10.1039/C4CC04623D

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