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Issue 76, 2014
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Deformable nature of various damaged DNA duplexes estimated by an electrochemical analysis on electrodes

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Abstract

We report bending flexibility of damaged duplexes possessing an apurinic/apyrimidinic (AP) site analogue, a cyclobutane pyrimidine dimer (CPD), and a pyrimidine(6-4)pyrimidone photoproduct (6-4PP). Based on the electrochemical evaluation on electrodes, the duplex flexibilities of the lesions increased in the following order: CPD < AP < 6-4PP. We discussed the possibility that the emerging local flexibility might be a good sign for UV-damaged DNA-binding proteins on duplexes.

Graphical abstract: Deformable nature of various damaged DNA duplexes estimated by an electrochemical analysis on electrodes

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Publication details

The article was received on 13 Jun 2014, accepted on 17 Jul 2014 and first published on 22 Jul 2014


Article type: Communication
DOI: 10.1039/C4CC04513K
Citation: Chem. Commun., 2014,50, 11126-11128
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    Deformable nature of various damaged DNA duplexes estimated by an electrochemical analysis on electrodes

    J. Chiba, S. Aoki, J. Yamamoto, S. Iwai and M. Inouye, Chem. Commun., 2014, 50, 11126
    DOI: 10.1039/C4CC04513K

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