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Issue 75, 2014
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Ruthenium bipyridyl complexes as photocleavable dimerizers: deactivation of DNA-binding peptides using visible light

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Abstract

We report a photolabile biselectrophilic Ru(II) complex that can be used for homo- or heterodimerization of cysteine-containing peptides. The resulting dimers can be efficiently disassembled by long-wavelength light. As proof-of-concept, we describe the preparation of homo- and heterodimeric bZIP peptides whose DNA-binding properties can be turned off using visible light.

Graphical abstract: Ruthenium bipyridyl complexes as photocleavable dimerizers: deactivation of DNA-binding peptides using visible light

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Publication details

The article was received on 13 Jun 2014, accepted on 23 Jul 2014 and first published on 28 Jul 2014


Article type: Communication
DOI: 10.1039/C4CC04512B
Citation: Chem. Commun., 2014,50, 10975-10978
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    Ruthenium bipyridyl complexes as photocleavable dimerizers: deactivation of DNA-binding peptides using visible light

    J. Mosquera, M. I. Sánchez, M. E. Vázquez and J. L. Mascareñas, Chem. Commun., 2014, 50, 10975
    DOI: 10.1039/C4CC04512B

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