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Issue 93, 2014
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Disulfide reshuffling triggers the release of a thiol-free anti-HIV agent to make up fast-acting, potent macromolecular prodrugs

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Abstract

The release of azidothymidine from macromolecular prodrugs was designed to respond to the intracellular disulfide reshuffling. This drug has no thiol groups, and a response to this trigger was engineered using a self-immolative linker. The resulting formulations were fast-acting, efficacious, and highly potent with regards to suppressing the infectivity of the virus.

Graphical abstract: Disulfide reshuffling triggers the release of a thiol-free anti-HIV agent to make up fast-acting, potent macromolecular prodrugs

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Publication details

The article was received on 04 Jun 2014, accepted on 26 Sep 2014 and first published on 26 Sep 2014


Article type: Communication
DOI: 10.1039/C4CC04280H
Citation: Chem. Commun., 2014,50, 14498-14500
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    Disulfide reshuffling triggers the release of a thiol-free anti-HIV agent to make up fast-acting, potent macromolecular prodrugs

    A. Kock, K. Zuwala, A. A. A. Smith, P. Ruiz-Sanchis, B. M. Wohl, M. Tolstrup and A. N. Zelikin, Chem. Commun., 2014, 50, 14498
    DOI: 10.1039/C4CC04280H

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