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Issue 66, 2014
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A modular tyrosine kinase deoxyribozyme with discrete aptamer and catalyst domains

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Abstract

We assess the utility of integrating a predetermined aptamer DNA module adjacent to a random catalytic DNA region for identifying new deoxyribozymes by in vitro selection. By placing a known ATP aptamer next to an N40 random region, an explicitly modular DNA catalyst for tyrosine side chain phosphorylation is identified. The results have implications for broader identification of deoxyribozymes that function with small-molecule substrates.

Graphical abstract: A modular tyrosine kinase deoxyribozyme with discrete aptamer and catalyst domains

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Publication details

The article was received on 03 Jun 2014, accepted on 25 Jun 2014 and first published on 30 Jun 2014


Article type: Communication
DOI: 10.1039/C4CC04253K
Citation: Chem. Commun., 2014,50, 9317-9320
  • Open access: Creative Commons BY license
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    A modular tyrosine kinase deoxyribozyme with discrete aptamer and catalyst domains

    V. Dokukin and S. K. Silverman, Chem. Commun., 2014, 50, 9317
    DOI: 10.1039/C4CC04253K

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