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Issue 74, 2014
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Development of a highly potent, selective, and cell-active Inhibitor of cysteine cathepsin L–A hybrid design approach

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Abstract

A hybrid-design approach is undertaken to develop a highly potent and selective inhibitor of human cathepsin L. Studies involving human breast carcinoma MDA-MB-231 cells establish that this inhibitor can successfully block intracellular cathepsin L activity, and retard the cell-migratory potential of these highly metastatic cells.

Graphical abstract: Development of a highly potent, selective, and cell-active Inhibitor of cysteine cathepsin L–A hybrid design approach

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Publication details

The article was received on 26 May 2014, accepted on 27 Jul 2014 and first published on 28 Jul 2014


Article type: Communication
DOI: 10.1039/C4CC04037F
Citation: Chem. Commun., 2014,50, 10875-10878
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    Development of a highly potent, selective, and cell-active Inhibitor of cysteine cathepsin L–A hybrid design approach

    D. Dana, S. De, P. Rathod, A. R. Davalos, D. A. Novoa, S. Paroly, V. M. Torres, N. Afzal, R. S. Lankalapalli, S. A. Rotenberg, E. J. Chang, G. Subramaniam and S. Kumar, Chem. Commun., 2014, 50, 10875
    DOI: 10.1039/C4CC04037F

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