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Issue 78, 2014
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A bifunctional curcumin analogue for two-photon imaging and inhibiting crosslinking of amyloid beta in Alzheimer's disease

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Abstract

In this report, we designed a highly bright bifunctional curcumin analogue CRANAD-28. In vivo two-photon imaging suggested that CRANAD-28 could penetrate the blood brain barrier (BBB) and label plaques and cerebral amyloid angiopathies (CAAs). We also demonstrated that this imaging probe could inhibit the crosslinking of amyloid beta induced either by copper or by natural conditions.

Graphical abstract: A bifunctional curcumin analogue for two-photon imaging and inhibiting crosslinking of amyloid beta in Alzheimer's disease

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Publication details

The article was received on 16 May 2014, accepted on 22 Jul 2014 and first published on 06 Aug 2014


Article type: Communication
DOI: 10.1039/C4CC03731F
Author version available: Download Author version (PDF)
Citation: Chem. Commun., 2014,50, 11550-11553
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    A bifunctional curcumin analogue for two-photon imaging and inhibiting crosslinking of amyloid beta in Alzheimer's disease

    X. Zhang, Y. Tian, P. Yuan, Y. Li, M. A. Yaseen, J. Grutzendler, A. Moore and C. Ran, Chem. Commun., 2014, 50, 11550
    DOI: 10.1039/C4CC03731F

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