Pd(II)-Catalyzed arylation of unactivated methylene C(sp3)–H bonds with aryl halides using a removable auxiliary

Qi Zhang; Xue-Song Yin; Sheng Zhao; Sheng-Long Fang; Bing-Feng Shi

doi:10.1039/C4CC03615H

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Pd(ii)-Catalyzed arylation of unactivated methylene C(sp³)–H bonds with aryl halides using a removable auxiliary†

Qi Zhang,‡^a Xue-Song Yin,‡^a Sheng Zhao,^a Sheng-Long Fang^a and Bing-Feng Shi*^ab

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* Corresponding authors

^a Department of Chemistry, Zhejiang University, Hangzhou 310027, China
E-mail: bfshi@zju.edu.cn

^b State Key Laboratory of Bioorganic & Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

Abstract

A Pd(II)-catalyzed arylation of methylene C(sp³)–H bonds in aliphatic amides directed by our newly developed PIP directing group with aryl iodides/bromides has been achieved. Arylation occurs efficiently with a broad range of aryl halides and amides.

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Article information

DOI: https://doi.org/10.1039/C4CC03615H
Article type: Communication
Submitted: 13 May 2014
Accepted: 09 Jun 2014
First published: 11 Jun 2014

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Chem. Commun., 2014,50, 8353-8355

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Pd(II)-Catalyzed arylation of unactivated methylene C(sp³)–H bonds with aryl halides using a removable auxiliary

Q. Zhang, X. Yin, S. Zhao, S. Fang and B. Shi, Chem. Commun., 2014, 50, 8353 DOI: 10.1039/C4CC03615H

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