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Issue 61, 2014
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Pd(II)-Catalyzed arylation of unactivated methylene C(sp3)–H bonds with aryl halides using a removable auxiliary

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Abstract

A Pd(II)-catalyzed arylation of methylene C(sp3)–H bonds in aliphatic amides directed by our newly developed PIP directing group with aryl iodides/bromides has been achieved. Arylation occurs efficiently with a broad range of aryl halides and amides.

Graphical abstract: Pd(ii)-Catalyzed arylation of unactivated methylene C(sp3)–H bonds with aryl halides using a removable auxiliary

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Publication details

The article was received on 13 May 2014, accepted on 09 Jun 2014 and first published on 11 Jun 2014


Article type: Communication
DOI: 10.1039/C4CC03615H
Citation: Chem. Commun., 2014,50, 8353-8355
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    Pd(II)-Catalyzed arylation of unactivated methylene C(sp3)–H bonds with aryl halides using a removable auxiliary

    Q. Zhang, X. Yin, S. Zhao, S. Fang and B. Shi, Chem. Commun., 2014, 50, 8353
    DOI: 10.1039/C4CC03615H

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