Jump to main content
Jump to site search

Issue 59, 2014
Previous Article Next Article

A “turn on/off” scorpion biosensor targeting point mutation of SMN genes for diagnosis of spinal muscular atrophy

Author affiliations

Abstract

A “turn on/off” biosensor for diagnosis of exon 7 of the SMN1 gene was developed by employing a “scorpion primer”. This scorpion primer was based on the principle of fluorescence resonance energy transfer using a fluorophore, a blocker and a quencher. It was successfully applied to detect 10 volunteer samples, and not only to in vitro testing.

Graphical abstract: A “turn on/off” scorpion biosensor targeting point mutation of SMN genes for diagnosis of spinal muscular atrophy

Back to tab navigation

Supplementary files

Publication details

The article was received on 08 May 2014, accepted on 04 Jun 2014 and first published on 13 Jun 2014


Article type: Communication
DOI: 10.1039/C4CC03472D
Citation: Chem. Commun., 2014,50, 8069-8072
  •   Request permissions

    A “turn on/off” scorpion biosensor targeting point mutation of SMN genes for diagnosis of spinal muscular atrophy

    C. Chen, C. Wang, Y. Chen, Y. Jong and S. Wu, Chem. Commun., 2014, 50, 8069
    DOI: 10.1039/C4CC03472D

Search articles by author

Spotlight

Advertisements