Issue 59, 2014

A “turn on/off” scorpion biosensor targeting point mutation of SMN genes for diagnosis of spinal muscular atrophy

Abstract

A “turn on/off” biosensor for diagnosis of exon 7 of the SMN1 gene was developed by employing a “scorpion primer”. This scorpion primer was based on the principle of fluorescence resonance energy transfer using a fluorophore, a blocker and a quencher. It was successfully applied to detect 10 volunteer samples, and not only to in vitro testing.

Graphical abstract: A “turn on/off” scorpion biosensor targeting point mutation of SMN genes for diagnosis of spinal muscular atrophy

Supplementary files

Article information

Article type
Communication
Submitted
08 May 2014
Accepted
04 Jun 2014
First published
13 Jun 2014

Chem. Commun., 2014,50, 8069-8072

A “turn on/off” scorpion biosensor targeting point mutation of SMN genes for diagnosis of spinal muscular atrophy

C. Chen, C. Wang, Y. Chen, Y. Jong and S. Wu, Chem. Commun., 2014, 50, 8069 DOI: 10.1039/C4CC03472D

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