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Issue 61, 2014
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A Hg(II)-mediated “signal-on” electrochemical glutathione sensor

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Abstract

We report the design and fabrication of a DNA-based electrochemical sensor for detection of glutathione. Sensor signaling relies on glutathione's ability to chelate mercury Hg(II), displacing it from the thymine–Hg(II)–thymine complex formed between the surface-immobilized DNA probes. Our results show that this sensor is sensitive and selective enough to be employed in saliva.

Graphical abstract: A Hg(ii)-mediated “signal-on” electrochemical glutathione sensor

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Publication details

The article was received on 04 May 2014, accepted on 04 Jun 2014 and first published on 05 Jun 2014


Article type: Communication
DOI: 10.1039/C4CC03329A
Citation: Chem. Commun., 2014,50, 8385-8387
  • Open access: Creative Commons BY-NC license
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    A Hg(II)-mediated “signal-on” electrochemical glutathione sensor

    H. R. Lotfi Zadeh Zhad and R. Y. Lai, Chem. Commun., 2014, 50, 8385
    DOI: 10.1039/C4CC03329A

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