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Issue 76, 2014
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Benzothiazole derivatives augment glucose uptake in skeletal muscle cells and stimulate insulin secretion from pancreatic β-cells via AMPK activation

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Abstract

Adenosine monophosphate-activated protein kinase (AMPK) has been identified as one of the major targets for antidiabetic drugs. This study describes two AMPK-activating agents 2-(benzo[d]thiazol-2-ylmethylthio)-6-ethoxybenzo[d]thiazole and 2-(propylthio)benzo[d]thiazol-6-ol, that increase the rate of glucose uptake in L6 myotubes and also augment glucose-stimulated insulin secretion in INS-1E β-cells and rat islets. We believe that such unique bi-functional compounds can be further used for the development of a new class of antidiabetic drugs.

Graphical abstract: Benzothiazole derivatives augment glucose uptake in skeletal muscle cells and stimulate insulin secretion from pancreatic β-cells via AMPK activation

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Publication details

The article was received on 03 May 2014, accepted on 30 Jul 2014 and first published on 30 Jul 2014


Article type: Communication
DOI: 10.1039/C4CC03310H
Citation: Chem. Commun., 2014,50, 11222-11225
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    Benzothiazole derivatives augment glucose uptake in skeletal muscle cells and stimulate insulin secretion from pancreatic β-cells via AMPK activation

    L. Pasternak, E. Meltzer-Mats, G. Babai-Shani, G. Cohen, O. Viskind, J. Eckel, E. Cerasi, S. Sasson and A. Gruzman, Chem. Commun., 2014, 50, 11222
    DOI: 10.1039/C4CC03310H

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