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Issue 74, 2014
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Mechanically resolving noncovalent bonds using acoustic radiation force

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Abstract

The resolution of molecular bonds and subsequent selective control of their binding are of great significance in chemistry and biology. We have developed a method based on the use of acoustic radiation force to precisely dissociate noncovalent molecular bonds. The acoustic radiation force is produced by extremely low-power ultrasound waves and is mediated by magnetic particles. We successfully distinguished the binding of antibodies of different subclasses and the binding of DNA duplexes with a single-base-pair difference. In contrast to most ultrasound applications in chemistry, the sonication probe is noninvasive and requires a sample volume of only a few microliters. Our method is thus viable for noninvasive and accurate control of molecular bonds that are widely encountered in biochemistry.

Graphical abstract: Mechanically resolving noncovalent bonds using acoustic radiation force

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Publication details

The article was received on 03 May 2014, accepted on 29 May 2014 and first published on 02 Jun 2014


Article type: Communication
DOI: 10.1039/C4CC03305A
Citation: Chem. Commun., 2014,50, 10786-10789
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    Mechanically resolving noncovalent bonds using acoustic radiation force

    L. De Silva, L. Yao and S. Xu, Chem. Commun., 2014, 50, 10786
    DOI: 10.1039/C4CC03305A

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