Issue 59, 2014
From the journal:

Chemical Communications

Dominant behaviours in the expression of human carbonic anhydrase hCA I activity

M. Yahia M. Abdelrahim,a   Muhammet Tanc,b   Jean-Yves Winum,c   Claudiu T. Supuran*c  and  Mihail Barboiu*a  

* Corresponding authors

a Adaptative Supramolecular Nanosystems Group, Institut Européen des Membranes, ENSCM/UMII/UMR-CNRS 5635, Pl. Eugène Bataillon, CC 047, 34095 Montpellier, Cedex 5, France
E-mail: mihail-dumitru.barboiu@univ-montp2.fr

b Università degli Studi di Firenze, Polo Scientifico, Laboratorio di Chimica Bioinorganica, Rm. 188, Via della Lastruccia 3, 50019 Sesto Fiorentino (Florence), Italy
E-mail: claudiu.supuran@unifi.it

c Institut des Biomolécules Max Mousseron (IBMM) UMR 5247 CNRS, Ecole Nationale Supérieure de Chimie de Montpellier, 8 rue de l'Ecole Normale, 34296 Montpellier Cedex, France

Abstract

Here we describe the screening via Dynamic Deconvolution of DCLs of inhibitors (CAIs) and activators (CAAs) of hCA I. The inhibitory effects dominate over the activating ones, while the CAAs may be identified in the absence of CAIs.

Graphical abstract: Dominant behaviours in the expression of human carbonic anhydrase hCA I activity

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Article information

DOI
https://doi.org/10.1039/C4CC03289F
Article type
Communication
Submitted
02 May 2014
Accepted
04 Jun 2014
First published
06 Jun 2014

Chem. Commun., 2014,50, 8043-8046

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Dominant behaviours in the expression of human carbonic anhydrase hCA I activity

M. Y. M. Abdelrahim, M. Tanc, J. Winum, C. T. Supuran and M. Barboiu, Chem. Commun., 2014, 50, 8043 DOI: 10.1039/C4CC03289F

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