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Issue 76, 2014
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Membrane lipid peroxidation by the peroxidase-like activity of magnetite nanoparticles

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Abstract

We report that Fe3O4 nanoparticles are able to catalyse lipid peroxidation in liposomes at acidic but not neutral pH. The oxidation is dependent on either pre-existing lipid peroxides or hydrogen peroxide as a substrate. This is the first evidence for metal oxide nanoparticles as peroxidase mimetics oxidising biomolecules in a relevant environment.

Graphical abstract: Membrane lipid peroxidation by the peroxidase-like activity of magnetite nanoparticles

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Publication details

The article was received on 25 Apr 2014, accepted on 30 Jul 2014 and first published on 30 Jul 2014


Article type: Communication
DOI: 10.1039/C4CC03082F
Citation: Chem. Commun., 2014,50, 11147-11150
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    Membrane lipid peroxidation by the peroxidase-like activity of magnetite nanoparticles

    L. Wang, Y. Min, D. Xu, F. Yu, W. Zhou and A. Cuschieri, Chem. Commun., 2014, 50, 11147
    DOI: 10.1039/C4CC03082F

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