Jump to main content
Jump to site search

Issue 76, 2014
Previous Article Next Article

2′-Deoxyuridine conjugated with a reactive monobenzocyclooctyne as a DNA building block for copper-free click-type postsynthetic modification of DNA

Author affiliations

Abstract

The carboxymethylmonobenzocyclooctyne group attached to the 5-position of a 2′-deoxyuridine in DNA allows rapid and efficient copper-free postsynthetic modification as demonstrated with a far-red emitting fluorescent azide probe. Upon labeling strong fluorescence intensity enhancement is observed.

Graphical abstract: 2′-Deoxyuridine conjugated with a reactive monobenzocyclooctyne as a DNA building block for copper-free click-type postsynthetic modification of DNA

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 17 Apr 2014, accepted on 24 Jul 2014 and first published on 30 Jul 2014


Article type: Communication
DOI: 10.1039/C4CC02855D
Citation: Chem. Commun., 2014,50, 11218-11221
  •   Request permissions

    2′-Deoxyuridine conjugated with a reactive monobenzocyclooctyne as a DNA building block for copper-free click-type postsynthetic modification of DNA

    C. Stubinitzky, G. B. Cserép, E. Bätzner, P. Kele and H. Wagenknecht, Chem. Commun., 2014, 50, 11218
    DOI: 10.1039/C4CC02855D

Search articles by author