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Issue 60, 2014
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Rhodium-catalyzed direct coupling of biaryl pyridine derivatives with internal alkynes

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Abstract

Axially chiral biaryls were synthesized by an isoquinoline or 2-pyridine-directed Rh(III)-catalyzed dual C–H cleavage and coupling with internal alkynes in good to excellent yields. Oxidation of isoquinoline derivatives with m-CPBA furnished their corresponding N-oxides, which could be utilized as Lewis base catalysts in asymmetric reactions.

Graphical abstract: Rhodium-catalyzed direct coupling of biaryl pyridine derivatives with internal alkynes

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Publication details

The article was received on 16 Apr 2014, accepted on 01 Jun 2014 and first published on 02 Jun 2014


Article type: Communication
DOI: 10.1039/C4CC02822H
Citation: Chem. Commun., 2014,50, 8204-8207
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    Rhodium-catalyzed direct coupling of biaryl pyridine derivatives with internal alkynes

    J. Zheng and S. You, Chem. Commun., 2014, 50, 8204
    DOI: 10.1039/C4CC02822H

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