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Issue 55, 2014
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Designed cell penetrating peptide dendrimers efficiently internalize cargo into cells

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Abstract

Redesigning linear cell penetrating peptides (CPPs) into a multi-branched topology with short dipeptide branches gave cell penetrating peptide dendrimers (CPPDs) with higher cell penetration, lower toxicity and hemolysis and higher serum stability than linear CPPs. Their use is demonstrated by delivering a cytotoxic peptide and paclitaxel into cells.

Graphical abstract: Designed cell penetrating peptide dendrimers efficiently internalize cargo into cells

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Publication details

The article was received on 15 Apr 2014, accepted on 15 May 2014 and first published on 15 May 2014


Article type: Communication
DOI: 10.1039/C4CC02780A
Citation: Chem. Commun., 2014,50, 7254-7257
  • Open access: Creative Commons BY license
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    Designed cell penetrating peptide dendrimers efficiently internalize cargo into cells

    G. A. Eggimann, E. Blattes, S. Buschor, R. Biswas, S. M. Kammer, T. Darbre and J. Reymond, Chem. Commun., 2014, 50, 7254
    DOI: 10.1039/C4CC02780A

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