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Issue 95, 2014
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Practical fluorescence detection of acrolein in human plasma via a two-step tethering approach

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Abstract

Acrolein, a cytotoxic α,β-unsaturated aldehyde and disease biomarker, was determined in plasma by means of a novel tethering strategy using Michael addition of the compound to a fluorescent dye, followed by immobilization of the product on microbeads via the aldehyde moiety. Elevation of blood acrolein was detected in mice treated with an anticancer agent cyclophosphamide, which releases acrolein upon activation. This method should be suitable for high-throughput diagnostic and clinical application.

Graphical abstract: Practical fluorescence detection of acrolein in human plasma via a two-step tethering approach

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Publication details

The article was received on 08 Apr 2014, accepted on 09 Jun 2014 and first published on 19 Jun 2014


Article type: Communication
DOI: 10.1039/C4CC02578D
Citation: Chem. Commun., 2014,50, 14946-14948
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    Practical fluorescence detection of acrolein in human plasma via a two-step tethering approach

    M. Togashi, T. Terai, H. Kojima, K. Hanaoka, K. Igarashi, Y. Hirata, Y. Urano and T. Nagano, Chem. Commun., 2014, 50, 14946
    DOI: 10.1039/C4CC02578D

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