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Issue 63, 2014
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Inherent anchorages in UiO-66 nanoparticles for efficient capture of alendronate and its mediated release

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Abstract

Zr-based MOF nanoparticles were applied as efficient carriers for alendronate delivery, and an unprecedented drug loading capacity was achieved thanks to the inherent drug anchorages of Zr–O clusters therein. The encapsulated drug featured with a pH-dependent release profile, and inhibited the growth of cancer cells more efficiently than the free drug.

Graphical abstract: Inherent anchorages in UiO-66 nanoparticles for efficient capture of alendronate and its mediated release

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Publication details

The article was received on 08 Apr 2014, accepted on 12 Jun 2014, published on 12 Jun 2014 and first published online on 12 Jun 2014


Article type: Communication
DOI: 10.1039/C4CC02570A
Citation: Chem. Commun., 2014,50, 8779-8782
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    Inherent anchorages in UiO-66 nanoparticles for efficient capture of alendronate and its mediated release

    X. Zhu, J. Gu, Y. Wang, B. Li, Y. Li, W. Zhao and J. Shi, Chem. Commun., 2014, 50, 8779
    DOI: 10.1039/C4CC02570A

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